The idea of establishing a museum in Ödemiş, which is on a fertile plain irrigated by the Little Maeander River running between Bozdağlar in north and Aydın Mountains in south, came up in 1974. First steps for the establishment of the Ödemiş Museum was taken when Lawyer Mutahhar Başoğlu, who was an ancient works collector and an ex-mayor donated his land in 1976 to the Treasury for the museum to be built on. The construction of the museum started in 1977 and it was completed in 1983. The museum consists of a basement floor with works depots and laboratories and a tent shaped entrance floor with showrooms and offices. Before the construction, the works of area were taken to İzmir Archaeology Museum and Tire Museum for precaution and after the construction was completed, these works were then transferred to Ödemiş Museum.

Ödemiş Museum was opened to visit in 2015 with a new conception after the extensive restoration and display arrangement works in 2013-2015. The archaeological and ethnographic works in the museum are exhibited in two separate sections. In the archaeological works section, works from the Bronze Age (3000 BC), Lydia (700-546 BC), Persian/Achaemenid (546-334 BC), Hellenistic (334-30 BC), Roman (133-395 BC), East Rome/Byzantine (395-1453 AD), all of which were obtained from Little Maeander Basin, are exhibited in chronological order. Coins from Hellenistic, Roman, East Rome/Byzantine and Ottoman Periods are also exhibited in this section.

In the ethnography section, various weapons, copper and silver objects, glass works, ornaments, hand embroidery, clothing examples, most of which are from the Ottoman Period, are exhibited. In the museum there are also examples of handicrafts from the Republic of Türkiye Period.

In the garden of the museum, marble statues, sarcophagi and on the side of column headings, a olive oil shop from the Roman Empire Period that was obtained with the excavations of Museum Directorate is exhibited with all its hardware.